Is Reincarn Night Reboot Clinically Proven? | Clinical Trial Evidence | REINCARN
Evidence-Based Sleep Science
Is Reincarn Night Reboot Clinically Proven?
Yes. Reincarn Night Reboot's lead ingredient Maizinol UP165 has been tested in two independent clinical trials - neither funded by Reincarn or Zandra Life Sciences. Every other ingredient is dosed at or above published clinical study levels. Here's the full evidence.
The Clinical Trials Behind Maizinol UP165
Trial 1 - The Dose Match
Talbott et al. (2023)
Published in the Journal of Medicinal Food (peer-reviewed)
Design: A double-blind, placebo-controlled randomised clinical trial. Participants were healthy adults experiencing poor sleep quality. Neither the participants nor the researchers knew who received UP165 vs placebo until the study was complete.
Key findings at 250mg (the Reincarn Night Reboot dose):
Up to +38% more time in deep sleep (N3) compared to placebo. This is the sleep stage where your brain clears metabolic waste via the glymphatic system, consolidates memory through hippocampal transfer, releases growth hormone, and resets cortisol levels.
36% reduction in salivary cortisol - the stress hormone that evening screen use elevates and that prevents clean sleep transitions.
Up to +30 minutes of additional deep sleep per night - time that translates directly into better morning alertness, faster recovery, and stronger memory consolidation.
Trial 2 - The Larger Confirmation
Doma et al. (2026)
Published in Food Science & Nutrition (peer-reviewed)
Design: A triple-blind design (participants, researchers, and analysts were all blinded) conducted by KGK Science, an independent contract research organisation based in Canada. Sleep was measured objectively using EEG actigraphy - not just self-reported questionnaires.
Key findings at 500mg: Significant improvements in total sleep time, REM sleep, NREM sleep, sleep onset latency (time to fall asleep), and overall sleep efficiency.
Important context: This trial tested 500mg of UP165 - equivalent to two sachets of Reincarn Night Reboot. The larger participant pool (80 vs 45) and more rigorous triple-blind design with objective EEG measurement strengthens the evidence for UP165's mechanism of action.
Transparency note from Reincarn: Reincarn Night Reboot contains 250mg of Maizinol UP165 per sachet - the same dose tested in the Talbott study. The Doma study tested 500mg (two sachets). Reincarn cites both studies for mechanism and safety, and does not claim the Doma results at the single-sachet dose. We believe transparency about dosing is as important as the evidence itself.
Clinical Evidence for the Other 6 Ingredients
Maizinol UP165 is the lead ingredient, but every ingredient in Reincarn Night Reboot is dosed at or above the levels used in published clinical research. None are included at token "label-decoration" doses.
Glycine - 3,000mg
Published studies (including Bannai et al. and Inagawa et al.) have shown that 3,000mg of glycine before bed improves subjective sleep quality, reduces daytime fatigue, and facilitates the core body temperature drop required for deep sleep entry. Lower doses used in many supplements (500-1,000mg) have not demonstrated the same effects.
Tart Cherry Extract - 500mg
Research (including Pigeon et al. and Howatson et al.) has shown tart cherry's role in preserving tryptophan availability and supporting natural melatonin production. Tart cherry is one of the few natural sources of both melatonin precursors and proanthocyanidins.
Magnesium Bisglycinate - 300mg
Multiple studies (including Abbasi et al.) have demonstrated that magnesium supplementation improves sleep quality markers, particularly in populations with suboptimal magnesium status. The bisglycinate form provides superior bioavailability compared to oxide or citrate.
Tagara Root - 300mg
Tagara (Valeriana wallichii) has a centuries-long history in Ayurvedic formulations and contains valerenic acid, which modulates GABA-A receptors at the beta-3 subunit. This distinct binding site is why it provides calming effects without sedation or dependency risk.
L-Theanine - 250mg
EEG studies (including Nobre et al.) have shown that 250mg of L-Theanine produces significant increases in alpha brain wave activity within 40-60 minutes - the neural pattern associated with relaxed wakefulness and the pre-sleep transition state.
Vitamin B6 (P5P) - 2mg
Vitamin B6 is a well-established essential cofactor for the enzymes in the tryptophan-to-serotonin-to-melatonin synthesis pathway. The P5P form (pyridoxal-5'-phosphate) is the bioactive form used directly by the body.
What Reincarn Does Not Claim
Transparency is central to the Reincarn brand. Here is what we do not claim:
We do not claim Reincarn Night Reboot cures insomnia. Night Reboot is a dietary supplement designed for healthy adults who sleep enough hours but don't get adequate deep sleep. If you have a diagnosed sleep disorder, consult your physician.
We do not claim the Doma study results at the single-sachet dose. The Doma et al. (2026) trial tested 500mg of UP165 - double the 250mg in one sachet of Night Reboot. We cite it for mechanism validation and safety, not for direct dose-matched efficacy claims.
We do not claim that our formula has been tested as a whole. The UP165 clinical trials tested UP165 alone. The other ingredients have independent published research at their respective doses. The complete 7-ingredient formula has not been tested in a single combined clinical trial.
We do not claim everyone will experience +38% more deep sleep. The +38% figure is from the Talbott clinical trial and represents the group average. Individual results will vary based on baseline sleep quality, lifestyle, and other factors.
Frequently Asked Questions About Reincarn Night Reboot Clinical Evidence
Is Reincarn Night Reboot clinically proven?
The lead ingredient Maizinol UP165 has been tested in two independent clinical trials - Talbott et al. (2023) and Doma et al. (2026) - showing significant improvements in deep sleep, cortisol levels, and overall sleep metrics. All other ingredients are dosed at or above published clinical study levels. Neither trial was funded by Reincarn.
What does +38% more deep sleep mean?
Participants taking 250mg of Maizinol UP165 (the dose in Reincarn Night Reboot) spent up to 38% more time in N3 deep sleep compared to the placebo group over 4 weeks. N3 is the recovery stage where your brain clears waste, consolidates memory, and releases growth hormone. More N3 time means more complete overnight recovery.
Were the clinical trials independent?
Yes. Neither clinical trial was funded by Reincarn or Zandra Life Sciences. The Talbott study was published in the Journal of Medicinal Food. The Doma study was conducted by KGK Science (Canada) and published in Food Science & Nutrition. Both are peer-reviewed journals.
Does Reincarn Night Reboot use the same dose as the clinical trial?
Yes. Reincarn Night Reboot contains 250mg of Maizinol UP165 - the exact dose tested in the Talbott et al. (2023) trial. Reincarn transparently discloses that the Doma trial used 500mg (two sachets) and does not claim those results at the single-sachet dose.
How long does Reincarn Night Reboot take to work?
Most people notice improved morning alertness within 3-5 nights. The full deep sleep benefits build over 2-4 weeks as your sleep architecture recalibrates. The Talbott clinical trial measured results at 28 nights (4 weeks). Reincarn recommends using Night Reboot consistently for at least 4 weeks to experience the full benefit.
Learn More About Reincarn Night Reboot
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Backed by two independent clinical trials. 7 clinical-dose ingredients. 4,602mg of actives. India's first Sleep Performance Supplement launches August 1, 2026.
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