Sleep Performance,
Measured
One formula. Seven ingredients. Seven biological pathways. Every claim on this page links to a published study.
Your Sleep Has Structure.
And It's Probably Broken.
Sleep is not a single state. It is a repeating cycle of four distinct stages, each serving a different biological function. When this architecture breaks down, no amount of "hours in bed" compensates.
Healthy sleep hypnogram: 4-5 cycles per night, ~90 minutes each. Early cycles are N3-heavy (deep recovery). Later cycles are REM-heavy (emotional processing).
The transition from wakefulness. Muscles relax, heart rate slows. Easily disrupted. A doorway, not a destination.
Sleep spindles and K-complexes fire. Body temperature drops. The foundation of sleep that most of your night is built on.
Emotional processing and procedural learning. The brain replays and recalibrates. Why you feel emotionally reset after good sleep.
What Breaks Sleep Architecture
Four forces systematically destroy your sleep cycles. You're likely exposed to all of them.
N3 deep sleep drops dramatically after 35. Van Cauter et al. found it fell from ~19% (ages 16-25) to ~3.4% (ages 36-50). You sleep the same hours but recover less.
Blue light (~480nm) activates melanopsin receptors in the retina, suppressing melatonin production. Your body's sleep signal arrives late, and the architecture shifts.
Elevated evening cortisol reduces N3 deep sleep and increases fragmentation. The HPA axis stays active when it should be quiet. You fall asleep tired and wake up tired.
Suppresses REM in the first half of the night, causes REM rebound and wakefulness in the second half. Feels like you slept. Your architecture says otherwise.
Why Melatonin Doesn't Fix This
That's it.
Rebuilds the full cycle.
Melatonin is a chronobiotic - it shifts the timing of sleep onset. A meta-analysis of 19 randomised controlled trials (Ferracioli-Oda et al., 2013; n=1,683) found it reduces the time to fall asleep by about 7 minutes.
It does not increase N3 deep sleep. It does not increase REM. Brzezinski et al. (2005) actually found sleep after melatonin contained more N2 and less N3. Melatonin opens the door to sleep. It does not rebuild what happens after you walk through it.
What Is a Sleep Performance Supplement?
A sleep aid helps you fall asleep. A Sleep Performance Supplement targets the biological architecture of sleep itself - the pathways that govern melatonin synthesis, core temperature regulation, neural inhibition, tryptophan metabolism, and deep sleep entry.
REINCARN
Seven clinically-studied ingredients. Seven biological pathways. 4,602 mg of total actives in one bedtime sachet. Designed not to sedate, but to support the full architecture of sleep - from melatonin synthesis to core temperature regulation to deep sleep entry.
The Proof Behind the Product
Night Reboot's lead ingredient, Maizinol UP165™, has been tested in two independent clinical trials -not funded by REINCARN. Here are the results.
Talbott et al. (2023)
Participants taking UP165 showed up to +30 minutes of additional deep sleep per night and up to 36% reduction in cortisol levels, measured via wearable sleep trackers and PSQI scores.
Read on PubMed →Doma et al. (2026)
Conducted by KGK Science using actigraphy with EEG. Showed significant improvements in total sleep time, REM, NREM, sleep onset latency, and sleep efficiency at 500 mg over 28 days.
Read Full Study →Night Reboot contains 250 mg of Maizinol UP165™ per sachet -the same dose tested in the Talbott study. The Doma study tested 500 mg (two sachets). We cite both studies because they establish the ingredient's mechanism and safety profile. We do not claim the Doma results at our single-sachet dose. Neither study was funded by REINCARN or Zandra Life Sciences.
7 Pathways. 7 Ingredients.
4,602 mg of Actives.
Most supplements throw a single ingredient at a complex problem. Sleep has at least seven biological bottlenecks -from melatonin synthesis to core temperature regulation to cortisol suppression. Night Reboot addresses each one with a dedicated, evidence-backed ingredient.
Activates the enzymes (tryptophan-5-hydroxylase and N-acetyltransferase) that produce your body's own melatonin. Binds MT2 receptors with fourfold higher affinity than MT1 -MT2 is the receptor linked to N3 deep sleep entry. Instead of replacing melatonin, it supports your body's production of it.
Vasodilator -increases blood flow to the skin, accelerating heat loss from the core. Deep sleep requires a core temperature drop of roughly 1°C. Glycine accelerates this same mechanism your body uses after a warm bath. Measured reduction in time to reach deep sleep in polysomnography studies.
Mg²⁺ ions potentiate GABA-A receptor activity (the brain's primary inhibitory system) and block excitatory NMDA receptors. Quiets the neural overactivity that keeps screen-users awake. Bisglycinate form chosen for superior absorption compared to oxide or citrate.
Increases alpha-wave (8–12 Hz) activity in the frontal cortex -the brain's calm-but-alert state. Screens push you into beta waves (anxious, wired). L-Theanine shifts you toward alpha, the bridge between wakefulness and natural sleep onset. No sedation, no blunted next-day cognition.
Valerenic acid acts as a positive allosteric modulator of GABA-A receptors -enhancing the receptor's response to GABA without directly activating the benzodiazepine binding site. This means calming effects without dependency risk. Works alongside Magnesium: one potentiates, the other modulates.
Contains procyanidin B-2, which inhibits IDO (indoleamine 2,3-dioxygenase) -the enzyme that breaks down tryptophan before it can become serotonin and melatonin. Preserves tryptophan for the melatonin pipeline. Maizinol activates the factory; Tart Cherry feeds it raw material. Synergistic, not redundant.
Pyridoxal phosphate (active B6) is the essential cofactor for aromatic L-amino acid decarboxylase -the enzyme that converts 5-HTP into serotonin. Without adequate B6, the conversion stalls regardless of tryptophan availability. This 2 mg dose ensures the synthesis pathway stays open.
A System, Not a Stack
Each ingredient resolves one specific bottleneck in the sleep pathway. Read as a sequence, they tell one story -from raw material to recovery.
Tart Cherry + Vitamin B6
Tart Cherry preserves tryptophan (by inhibiting IDO). B6 ensures the enzymes that convert tryptophan → serotonin → melatonin stay active. Together, they load the raw material into the melatonin production line.
Maizinol UP165™
Upregulates tryptophan-5-hydroxylase and N-acetyltransferase -the two rate-limiting enzymes. Binds MT2 receptors to direct the signal specifically toward N3 deep sleep. The pipeline has material; now the factory is running.
Glycine + Magnesium
Glycine drops core temperature via vasodilation -the physical prerequisite for deep sleep entry. Magnesium quiets excitatory NMDA signalling and potentiates GABA-A. The body is now physiologically ready for deep sleep.
L-Theanine + Tagara
L-Theanine shifts brainwave activity from beta (wired) to alpha (calm). Tagara modulates GABA-A receptors to reduce residual neural excitability. Together, they remove the screen-induced interference that prevents the first three phases from working.
Full Dose Transparency
No proprietary blends. No pixie-dusting. Every ingredient at its evidence-backed dose, with the published reference.
Standardised extract of Zea mays leaf containing 6-MBOA. Supports endogenous melatonin production by activating the enzymatic machinery (tryptophan hydroxylase, N-acetyltransferase) rather than supplying exogenous melatonin. Shows fourfold higher binding affinity for MT2 over MT1 receptors in preclinical assays.
Read Full Deep Dive →At 3g, glycine acts as a vasodilator that increases peripheral blood flow, accelerating core body temperature reduction. PSG studies show subjective and objective sleep quality improvements including reduced sleep onset latency and increased sleep efficiency.
Read Full Deep Dive →Mg²⁺ acts as a natural NMDA receptor antagonist and GABA-A receptor agonist. Reduces excitatory neural activity while enhancing inhibitory signalling. Bisglycinate form selected for chelated absorption -clinically shown to improve sleep quality in supplementation trials.
Read Full Deep Dive →At 250 mg, L-Theanine significantly increases alpha-wave activity within 30 minutes of ingestion -measured by EEG. Promotes a state of relaxed alertness without sedation. Does not impair next-day cognitive performance.
Contains procyanidin B-2, which dose-dependently inhibits IDO (indoleamine 2,3-dioxygenase) -preserving tryptophan for serotonin and melatonin synthesis. In vivo reduction of the kynurenine/tryptophan ratio confirms the mechanism. Pilot RCT showed +84 minutes total sleep time.
Read Full Deep Dive →Valeriana wallichii -the Ayurvedic relative of Valeriana officinalis. Active compound valerenic acid is a positive allosteric modulator of GABA-A receptors at the beta-3 subunit (distinct from the benzodiazepine binding site). Calming effect without dependency risk.
Read Full Deep Dive →Pyridoxal-5'-phosphate (PLP) is the essential cofactor for aromatic L-amino acid decarboxylase (AADC), the enzyme responsible for converting 5-HTP into serotonin -the direct precursor to melatonin. Without adequate B6, the tryptophan → serotonin → melatonin conversion pathway stalls at the 5-HTP stage regardless of substrate availability.
| Ingredient | Dose | Pathway | Published Reference |
|---|---|---|---|
| Maizinol UP165™ | 250 mg | The Melatonin Factory | Talbott 2023, PMC9889011 |
| Glycine | 3,000 mg | The Temperature Drop | Kawai 2015, PMC4397399 |
| Magnesium Bisglycinate | 300 mg | The GABA Switch | Abbasi 2012, PMC3703169 |
| L-Theanine | 250 mg | The Alpha State | Nobre 2008, PMID 18296328 |
| Tart Cherry Extract | 500 mg | The Melatonin Feed | Losso 2018, PMC5617749 |
| Tagara Root | 300 mg | The Cortisol Brake | Benke 2009, PMID 18602406 |
| Vitamin B6 | 2 mg | The Synthesis Key | Allen 2010, PMID 20403077 |
| Total Actives | 4,602 mg | per sachet | |
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Published Studies Cited on This Page
Every claim on this page is linked to a peer-reviewed, published study. Full references below.
[1] Talbott SM, Talbott JA, Stephens BJ, Oddou MP. Effect of coordinated aqueous extract of corn leaf (Zea mays L.) on sleep quality: a randomized, double-blind, placebo-controlled study. Journal of Medicinal Food. 2023;26(12). PMC9889011
[2] Doma KM, et al. A triple-blind, randomized, placebo-controlled clinical trial evaluating UP165 corn leaf extract on sleep quality. Food Science & Nutrition. 2026. PMC12759108
[3] Kawai N, Sakai N, Okuro M, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015;40(6):1405-1416. PMC4397399
[4] Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences. 2012;17(12):1161-1169. PMC3703169
[5] Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition. 2008;17(S1):167-168. PMID 18296328
[6] Losso JN, Finley JW, Karki N, et al. Pilot study of tart cherry juice for the treatment of insomnia and investigation of mechanisms. American Journal of Therapeutics. 2018;25(2):e194-e201. PMC5617749
[7] Benke D, Barberis A, Kopp S, et al. GABA-A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2009;56(1):174-181. PMID 18602406
[8] Allen GFG, Neergheen V, Oppenheim M, et al. Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells. Journal of Neurochemistry. 2010;114(1). PMID 20403077 Cited for mechanism: establishes PLP (active B6) as essential cofactor for AADC, the enzyme converting 5-HTP to serotonin.
[9] Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS ONE. 2013;8(5):e63773. PMID 23691095
[10] Brzezinski A, Vangel MG, Wurtman RJ, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Medicine Reviews. 2005;9(1):41-50. PMID 15649737
[11] Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 2000;284(7):861-868. PMID 10938176