What is Maizinol and Which Supplements Contain It in India? | REINCARN
What is Maizinol® and Which Supplements Contain It in India?
Maizinol® (UP165) is a patented, standardised corn leaf extract clinically studied to support deep sleep. It is the only ingredient of its kind with two independent RCTs confirming benefits at the deep sleep (N3) stage. Here is everything you need to know about how it works, what the evidence says, and where to find it in India.
What it is: Maizinol® is a patented extract of Zea mays (corn) leaves, manufactured by Unigen Inc. ↗ Its internal designation is UP165.
How it works: Maizinol binds to MT2 melatonin receptors with approximately 4x higher affinity than supplemental melatonin, supporting endogenous melatonin production without introducing the hormone externally.
Clinical evidence: Two independent RCTs at 250mg. Talbott et al. 2023 and Doma et al. 2026. Up to +38% more N3 deep sleep time.
In India: Reincarn Night Reboot is India's first supplement formulated with Maizinol at the 250mg clinical dose.
What Exactly is Maizinol?
Origin and composition
Maizinol® is a standardised, water-soluble extract derived from the leaves of Zea mays L. (common corn/maize). It is produced by Unigen Inc. ↗, a US-based nutraceutical ingredient company with a research focus on natural bioactives. The extract is standardised to its active phenolic compounds, which are the components responsible for its melatonin receptor activity.
Maizinol carries the internal research designation UP165. Both the ingredient name "Maizinol" and the compound designation "UP165" refer to the same patented extract.
Why corn leaves?
Corn (Zea mays) has a long history of use in traditional medicine across multiple cultures, including in Ayurveda (as "Makai") for its diuretic and calming properties. Unigen's research team identified specific phenolic compounds in the leaves of the corn plant with structural similarities to melatonin receptor ligands, leading to the development and patenting of the UP165 extract.
What makes it different from melatonin?
Maizinol does not contain melatonin. It contains compounds that interact with melatonin receptors, particularly the MT2 receptor, which is associated with the deep sleep (N3) stage. The key distinction: Maizinol supports the melatonin signalling pathway at the receptor level without introducing exogenous melatonin hormone. Research from Unigen shows the bioactive compounds in Maizinol bind to MT2 receptors with approximately 4x higher affinity than melatonin itself.
This matters because standard melatonin supplements introduce a hormone from outside the body, which can suppress natural melatonin production over time. Maizinol amplifies the body's own melatonin signal without replacing it.
For a full comparison, see: Does Reincarn Night Reboot contain melatonin? →
The Clinical Evidence
Published in Antioxidants, 2023. Independently conducted; not funded by Reincarn or Zandra Life Sciences. Participants received either 250mg Maizinol UP165 or placebo daily for 4 weeks, with outcomes measured via validated sleep quality questionnaires and salivary biomarkers.
Reference: PMC9889011 ↗
Published in Food Science & Nutrition, 2026. A larger, more rigorous replication study conducted by KGK Science, an independent Canadian CRO. Confirmed improvements in total sleep time and sleep efficiency at the 250mg dose. The triple-blind design represents the highest standard of clinical trial methodology for sleep research.
Both trials evaluated UP165 as a standalone ingredient. Reincarn Night Reboot includes Maizinol as part of a 7-ingredient formula. The complete combined formula has not been evaluated in a single clinical trial. Each of the other 6 ingredients is independently dosed at or above levels used in published research.
Which Supplements Contain Maizinol in India?
As of June 2026, Reincarn Night Reboot is the only supplement available in India formulated with Maizinol UP165 at the 250mg clinical dose. All other currently known Maizinol-containing supplements are produced by US brands for the US market and are not available through Indian retail channels.
Reincarn Night Reboot is available exclusively at reincarn.in. The founding batch (500 units) ships August 1, 2026.
Maizinol and Deep Sleep: The Science
What is N3 deep sleep and why does it matter?
Sleep is divided into cycles, each containing lighter stages (N1, N2) and one deep stage (N3, also called slow-wave sleep or SWS). N3 is the stage where the brain clears metabolic waste via the glymphatic system, consolidates long-term memory, releases growth hormone, resets cortisol, and performs cellular repair. Most adults, particularly those with high screen exposure or irregular sleep schedules, are deficient in N3 time rather than total sleep time.
Standard melatonin supplements do not meaningfully increase N3 time. They primarily affect the onset and timing of sleep, not the architecture once asleep. Maizinol's mechanism, via MT2 receptor binding, is specifically associated with the promotion of N3 sleep in clinical research.
Why the MT2 receptor specifically?
There are two primary melatonin receptors: MT1 and MT2. MT1 receptor activation is associated with circadian rhythm regulation and sleep onset. MT2 receptor activation is more specifically associated with deep sleep promotion and the shift from light sleep (N2) to slow-wave sleep (N3). Maizinol's selective affinity for MT2 over MT1 is a key reason its clinical outcomes focus on deep sleep quality rather than simply sleep onset.
For more on how Maizinol fits into the full Night Reboot formula, see: Reincarn Night Reboot full ingredient breakdown →
Frequently Asked Questions
Maizinol (UP165) is a patented, standardised extract of Zea mays (corn) leaves, manufactured by Unigen Inc. It binds to MT2 melatonin receptors with approximately 4x higher affinity than supplemental melatonin, supporting deep sleep (N3) without introducing exogenous melatonin hormone.
Yes. Reincarn Night Reboot, available at reincarn.in, is India's first supplement formulated with Maizinol UP165 at the 250mg clinical dose. Other Maizinol-containing supplements (Thorne, Univera) are US products not available in Indian retail.
The dose used in both published clinical trials is 250mg of Maizinol UP165 per day. Reincarn Night Reboot contains exactly 250mg per serving - the same dose studied in the Talbott et al. 2023 and Doma et al. 2026 trials.
No. Maizinol does not contain melatonin. It contains phenolic compounds that bind to melatonin receptors, particularly MT2, supporting the body's own melatonin signalling pathway without introducing the hormone externally.
Maizinol UP165 has undergone extensive safety testing by Unigen Inc. with no adverse effects reported at the 250mg dose in clinical trials. It is non-habit forming. As with any supplement, consult a healthcare professional before use if you have a medical condition or are taking prescription medications.
Maizinol is manufactured and patented by Unigen Inc., a US-based nutraceutical ingredient company. The full Reincarn Night Reboot supplement (which contains Maizinol) is manufactured by Siddhayu Life Sciences (Baidyanath Group) in India.
References
- Talbott, S.M. et al. (2023). "UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State." Antioxidants, 12(3), 580. PMC9889011 ↗
- Doma, K. et al. (2026). Triple-blind, randomised, placebo-controlled trial of Maizinol UP165 at 250mg. Food Science & Nutrition. KGK Science Inc., Canada.
- Unigen Inc. Maizinol ingredient page. unigen.net/ingredients/maizinol/ ↗
- Unigen Inc. "Solutions in the Face of Sleeplessness - Maizinol as a Natural Choice for Restorative Sleep." unigen.net ↗
Reincarn Night Reboot is a food supplement, not a medicine. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. The clinical trials referenced were conducted on Maizinol UP165 as a standalone ingredient; the complete 7-ingredient Night Reboot formula has not been evaluated in a single combined trial. Manufactured by Siddhayu Life Sciences in an FSSAI-approved, GMP-certified facility.